Four Pioneering Biohacking Mental Health Treatments Providing Relief Using NAD+, Ketamine, Psilocybin, and EPA Fatty Acids

Four Pioneering Biohacking Mental Health Treatments Providing Relief Using NAD+, Ketamine, Psilocybin, and EPA Fatty Acids

The mental health of people across the world suffered greatly in 2020, and the pandemics’ effects on our collective and individual well-being forced the world to confront mental and physical health challenges like never before. But…

Can mental health be relieved through biohacking treatments?

Innovative thinkers have stepped up to the challenge!

We all know that there’s the kind of anxiety we feel in a dangerous situation when our minds and bodies are on high alert. 

And then there’s anxiety, the permanent fear we experience during everyday situations when the threat of danger isn’t actually real. 

The first type of anxiety is a natural part of the “fight or flight” response programmed into us to survive a crisis. 

But, the second type is a mental health issue that affects every aspect of our lives. 

IV therapy has become a great available choice for anxiety relief.

IV therapy depends mostly on vitamins & minerals, in addition to many other nutrients that relieve anxiety and depression symptoms.

So, you’re not only getting mental improvements, but your physical body improves too!

If you grapple with anxiety, depression, PTSD, or addiction, the most pioneering treatments available may offer welcome symptom relief:

Let’s dig deeper into the 4 most innovative treatments out there.


According to WebMD, NAD+ is a coenzyme that plays a great role in the chemical process that generates energy and alleviates anxiety symptoms in two key ways:

• Influencing sirtuin (SIRT) activity:

Low levels of serotonin (a neurotransmitter in the brain) contribute to anxiety.

Sirtuins are a family of signaling proteins involved in metabolic regulation. A specific type of sirtuin, SIRT1, can bolster low serotonin levels to improve your mood and this depends on NAD+ to carry out this function.

• Oxidative stress reduction:

Free radicals (in the form of oxidative stress) cause cellular damage.

And there’s a strong relationship between anxiety and brain inflammation (and neurotoxicity) caused by this oxidative stress. 

NAD+ IV will solve this problem by reducing the damage caused by free radicals and promoting cellular repair and functionality. 

IV therapy featuring NAD+ offers effective benefits for mental health, supports physical health with vitamins and minerals, and makes you feel more energy and vitality.

But, Why Does NAD+ Help The Brain?

The National Library of Medicine says that  NAD+ is a vital redox cofactor for metabolism and ATP production in brain cells.

It’s a key substrate for at least four families of enzymes involved in health span and longevity.

In addition, SIRT 1 has been shown to be involved in regulating long-term potentiation, learning, and memory.


Ketamine is effective for treating both depression & anxiety.

But, how does Ketamine work?

Medscape says that Ketamine binds to NMDA receptors in the brain to increase the amount of glutamate (a neurotransmitter in the spaces between neurons).

Glutamate then activates connections in the AMPA receptor. 

This leads to the release of other molecules that help neurons communicate with each other along new pathways which affect mood, thought patterns, and cognition!

Why Does Ketamine Help The Brain?

According to Scientific American, a leading theory proposes that Ketamine stimulates the regrowth of synapses ( synapses are the connections between neurons), effectively rewiring the brain.

Another reason is that it works differently than existing antidepressants. Rather than affecting one of the “monoamine” neurotransmitters (like serotonin, norepinephrine, and dopamine), it affects glutamate, the most common chemical messenger in the brain. 

In its turn, Glutamate plays a key role in the changes synapses undergo in response to experiences that underlie learning and memory. 


According to a study by The National Library for Medicine published in 2022, Psilocybin treatment decreases depression (and can maintain a decrease in depression) one, three, six, and 12 months after Psilocybin treatment.

Psilocybin produces significant and immediate effects, & it also has a long duration, which suggests that it may be a uniquely useful treatment for depression.

Psilocybin increases attitudes about self and life, mood, relationships, and behavior too.

Why Does Psilocybin Help The Brain?

According to the University of California San Francisco, Psilocybin fosters greater connections between different regions of the brain in depressed people.

This helps free patients up from long-held patterns of rumination and excessive self-focus, giving them healthier flexibility in their thought patterns.

David Nutt, DM, head of the Imperial Centre for Psychedelic Research says: “For the first time we find that psilocybin works differently from conventional antidepressants – making the brain more flexible and fluid, and less entrenched in the negative thinking patterns associated with depression”.

1000 mg Of EPA Fatty Acids Per Day

What makes fatty acids a great choice for mental health issues is that they can easily travel through the brain cell membrane and interact with mood-related molecules inside your brain. 

Recently, Oxford published a study that discussed fatty acid’s benefits throughout life.

Fatty acids have been studied in many mood disorders, such as postpartum depression, bipolar disorder, schizophrenia, obsessive-compulsive disorder, attention deficit disorder, and borderline personality disorder.

Why Do EPAs Help The Brain?

The brain contains more than 100 billion cells and omega-3 fatty acids are the building blocks of these cells. 

Fatty Acids bind to cell membranes increasing their fluidity, which is important for the functioning of brain cells.

PubMed says that essential fatty acids (EFAs) are essential for the maintenance of optimal health but they cannot be synthesized by the body and must be obtained from dietary sources. 

Clinical observation studies have related imbalanced intake of fatty acids to impaired brain performance and diseases.

Dealing with depression, anxiety, or both can make simple daily tasks a struggle. Sometimes, leaving the house, or just the bed feels impossible. 


When you can’t make it to Superhuman IV’s physical location at 5th + Broadway, we will come to you with our in-home services and the most innovative treatments available out there.

One of our goals at Superhuman IV is to help as many people as possible with mental health battles with natural, nutrient-based iv therapy that has lasting results. 

We want to serve you the way we have served our other clients who have seen significant results. 

One of our favorite stories is about Maria, a 26-year-old who has battled severe fatigue and depression for decades. After one of our mini NAD+ mental health protocol treatments, Maria saw a night and day difference. 

Maria says that Superhuman IV has changed the game, she was struggling with depression, anxiety, and panic attacks.

But,  after the mental health 3-day NAD+ package, she hasn’t had a depressing day or panic attack since. 

NAD+ IV Treatment helped Maria change her thought patterns, sleep, and mood!

Read Maria’s story with Superhuman IV using the link: MARIA’S REVIEW

*These statements have not been evaluated by the FDA and are not intended to diagnose, cure or treat deep depression or other psychological disorders. We recommend you consult with your therapist or doctor before beginning any treatment. 


NAD+ IV  : Affects mental health, supports physical health and helps people get super vital and energetic (Webmd: NADH, Overview, Uses, Side Effects, And More.., 2020, view reference)

(The National Library of Medicine: NAD+ in Brain Aging and Neurodegenerative Disorders, 2020, view reference)

Ketamine affects mood, thought patterns, and cognition  (Medscape: Ketamine Linked to Reduced Suicidal Thoughts, Depression, Anxiety, 2022, view reference)

(Scientific American: Behind the Buzz: How Ketamine Changes the Depressed Patient’s Brain, 2019, view reference)

Both Ketamine and psilocybin play a key role in reducing anxiety and depression levels. (Mayo Clinic: Treatment resistant-depression, 2021, view reference)

Psilocybin affects attitude about self & life, relationships, behaviors, and mood.

(National Library of Medicine: Psilocybin for Treating Psychiatric Disorders: A Psychonaut Legend or a Promising Therapeutic Perspective?, 2022, view reference)

(Medscape: Psilocybin Effective Up to 12 Weeks in Severe Depression, 2022, view reference)

(University of California San Francisco, Psilocybin Rewires the Brain for People with Depression, 2022, view reference)

EPA Fatty Acids help with depression, heart disease, rheumatoid arthritis, menstrual pain, and many mood disorders. (Oxford Academic: Omega-3 Fatty Acids EPA and DHA: Health Benefits Throughout Life, 2012, view reference)(PubMed: Essential fatty acids and human brain, 2009, view reference)

Can NAD+ Benefit Those Suffering from HIV and Aging?

Can NAD+ Benefit Those Suffering from HIV and Aging?

Fourteen years ago, September 18, 2008, the National Institute of Aging (NIA) launched National HIV and Aging Awareness Day. In the late 80s, very few people that were diagnosed with what is now known as human immunodeficiency virus (HIV) were lucky to survive past a year. During that time, many of the people living with HIV were taking highly toxic prescriptions and staying silent in hopes of surviving an epidemic. As treatments got better so did the lives of those suffering in silence. Although the HIV drugs used now are more effective and less toxic than drugs used in earlier times, they still may have long-term effects that we do not yet fully understand. So it’s not a surprise as we are hearing more people surviving to the normal lifespan.

The Ryan White HIV/AIDS Program (ADAP) serves over half a million individuals over 50 with HIV. In 2019, 92.2% of those aged 50 and older receiving HIV medical care were virally suppressed, which was higher than the national average (88.1%).

According to the Centers for Disease Control and Prevention (CDC), in 2018, over half (51%) of people in the United States that are diagnosed HIV were aged 50 and older. In addition, people aged 50 and older accounted for 17% of the 37,968 new HIV diagnoses. Though new HIV diagnoses are declining among people aged 50 and older, around 15% of diagnosis were those classified to be HIV and aging group.

People living with HIV have a lot more issues related to their aging than their HIV-related illnesses. Many individuals with HIV who have been living with it since the very beginning of the epidemic have unique difficulties, both physically and psychologically. 

How Does HIV Affect the Body’s Aging Process

HIV has an “early and substantial” impact on aging in infected people, accelerating biological changes in the body associated with normal aging within just two to three years of infection, according to a study by UCLA researchers and colleagues.

The findings suggest that new HIV infection may rapidly cut nearly five years off an individual’s life span relative to an uninfected person.

“Our work demonstrates that even in the early months and years of living with HIV, the virus has already set into motion an accelerated aging process at the DNA level,” said lead author Elizabeth Crabb Breen, a professor emerita at UCLA’s Cousins Center for Psychoneuroimmunology and of psychiatry and biobehavioral sciences at the David Geffen School of Medicine at UCLA.

“This emphasizes the critical importance of early HIV diagnosis and an awareness of aging-related problems, as well as the value of preventing HIV infection in the first place.”

Living with HIV presents certain challenges, no matter what your age. But older people with HIV may face different issues than their younger counterparts, including greater social isolation and loneliness. The aging process itself can lower energy levels, restrict social encounters, and cause decreased physical and mental abilities. This means that older people living with HIV may suffer more emotional problems and physical stresses than others do.

Stigma can also make things difficult. There is the stigma from shame of living with HIV, AIDS, and older adults. This can make it difficult for older people to find support. First of all, they may be ashamed and hesitate to tell anyone that they live with HIV. Secondly, they may not be comfortable in support groups that include younger people.

In the late 80s many HIV cocktails (ART) regimens required people to take several pills around the clock. Even today with the huge improvements in HIV drugs that now allow most people to live long and healthy lives with HIV, there are several ways in which living and aging with HIV are different than others over 50 years old.

HIV and its treatment can also have effects on the brain. Researchers estimate that between 25 and 50% of people with HIV have HIV-Associated Neurocognitive Disorder (HAND), a spectrum of cognitive, motor, and/or mood disorders categorized into three levels: asymptomatic, mild, and HIV-associated dementia. Researchers are studying how HIV and its treatment affect the brain, including the effects on older people living with HIV.

Can NAD+ Slow Aging for those Aging with HIV?

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme that’s been shown to slow aging and help people fight the ill effects of aging. As biohacking evolves it’s been found to mitigate age-related disorders by regenerating the human body’s mitochondria. NAD+ is a key enzyme found in human cells and has been shown to reduce the amount of age-related tissue damage and by increasing the nutrients that keep skin looking young. It also improves muscle function and endurance and helps ward off age-related diseases. Recent research has shown that NAD+’s rehabilitation power extends the cells.

“We report that HIV-1 infection of human cells in vitro leads to significant decreases in the intracellular concentration of NAD. This decrease varies with viral load and HIV strain. In tissue culture, cells lacking CD4 receptors or cells incubated with heat inactivated virus do not demonstrate this decrease in NAD. Nicotinamide, the amide form of the vitamin niacin, increases intracellular NAD levels in uninfected cells as expected. Our data demonstrate that nicotinamide also maintains increased intracellular NAD concentrations in HIV infected cells. We conclude that HIV induces a state of intracellular pellagra which is reversed by the administration of nicotinamide.”

The team examined five epigenetic measures of aging. Four of them are what are known as epigenetic “clocks,” each of which uses a slightly different approach to estimate biological age acceleration in years, relative to chronological age. The fifth measure assessed the length of telomeres, the protective cap-like ends of chromosomes that become progressively shorter with age as cells divide, until they become so short that division is no longer possible.

“Our access to rare, well-characterized samples allowed us to design this study in a way that leaves little doubt about the role of HIV in eliciting biological signatures of early aging,” said senior author Beth Jamieson, a professor in the division of hematology and oncology at the Geffen School. “Our long-term goal is to determine whether we can use any of these signatures to predict whether an individual is at increased risk for specific aging-related disease outcomes, thus exposing new targets for intervention therapeutics.”

If you feel good about your age, it can help your health. As the saying goes, you’re only as old as you feel!


Research from the National Library of Medicine*

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