Four Pioneering Biohacking Mental Health Treatments Providing Relief Using NAD+, Ketamine, Psilocybin, and EPA Fatty Acids

Four Pioneering Biohacking Mental Health Treatments Providing Relief Using NAD+, Ketamine, Psilocybin, and EPA Fatty Acids

The mental health of people across the world suffered greatly in 2020, and the pandemics’ effects on our collective and individual well-being forced the world to confront mental and physical health challenges like never before. But…

Can mental health be relieved through biohacking treatments?

Innovative thinkers have stepped up to the challenge!

We all know that there’s the kind of anxiety we feel in a dangerous situation when our minds and bodies are on high alert. 

And then there’s anxiety, the permanent fear we experience during everyday situations when the threat of danger isn’t actually real. 

The first type of anxiety is a natural part of the “fight or flight” response programmed into us to survive a crisis. 

But, the second type is a mental health issue that affects every aspect of our lives. 

IV therapy has become a great available choice for anxiety relief.

IV therapy depends mostly on vitamins & minerals, in addition to many other nutrients that relieve anxiety and depression symptoms.

So, you’re not only getting mental improvements, but your physical body improves too!

If you grapple with anxiety, depression, PTSD, or addiction, the most pioneering treatments available may offer welcome symptom relief:

Let’s dig deeper into the 4 most innovative treatments out there.

NAD+ IV

According to WebMD, NAD+ is a coenzyme that plays a great role in the chemical process that generates energy and alleviates anxiety symptoms in two key ways:

• Influencing sirtuin (SIRT) activity:

Low levels of serotonin (a neurotransmitter in the brain) contribute to anxiety.

Sirtuins are a family of signaling proteins involved in metabolic regulation. A specific type of sirtuin, SIRT1, can bolster low serotonin levels to improve your mood and this depends on NAD+ to carry out this function.

• Oxidative stress reduction:

Free radicals (in the form of oxidative stress) cause cellular damage.

And there’s a strong relationship between anxiety and brain inflammation (and neurotoxicity) caused by this oxidative stress. 

NAD+ IV will solve this problem by reducing the damage caused by free radicals and promoting cellular repair and functionality. 

IV therapy featuring NAD+ offers effective benefits for mental health, supports physical health with vitamins and minerals, and makes you feel more energy and vitality.

But, Why Does NAD+ Help The Brain?

The National Library of Medicine says that  NAD+ is a vital redox cofactor for metabolism and ATP production in brain cells.

It’s a key substrate for at least four families of enzymes involved in health span and longevity.

In addition, SIRT 1 has been shown to be involved in regulating long-term potentiation, learning, and memory.

Ketamine 

Ketamine is effective for treating both depression & anxiety.

But, how does Ketamine work?

Medscape says that Ketamine binds to NMDA receptors in the brain to increase the amount of glutamate (a neurotransmitter in the spaces between neurons).

Glutamate then activates connections in the AMPA receptor. 

This leads to the release of other molecules that help neurons communicate with each other along new pathways which affect mood, thought patterns, and cognition!

Why Does Ketamine Help The Brain?

According to Scientific American, a leading theory proposes that Ketamine stimulates the regrowth of synapses ( synapses are the connections between neurons), effectively rewiring the brain.

Another reason is that it works differently than existing antidepressants. Rather than affecting one of the “monoamine” neurotransmitters (like serotonin, norepinephrine, and dopamine), it affects glutamate, the most common chemical messenger in the brain. 

In its turn, Glutamate plays a key role in the changes synapses undergo in response to experiences that underlie learning and memory. 

Psilocybin 

According to a study by The National Library for Medicine published in 2022, Psilocybin treatment decreases depression (and can maintain a decrease in depression) one, three, six, and 12 months after Psilocybin treatment.

Psilocybin produces significant and immediate effects, & it also has a long duration, which suggests that it may be a uniquely useful treatment for depression.

Psilocybin increases attitudes about self and life, mood, relationships, and behavior too.

Why Does Psilocybin Help The Brain?

According to the University of California San Francisco, Psilocybin fosters greater connections between different regions of the brain in depressed people.

This helps free patients up from long-held patterns of rumination and excessive self-focus, giving them healthier flexibility in their thought patterns.

David Nutt, DM, head of the Imperial Centre for Psychedelic Research says: “For the first time we find that psilocybin works differently from conventional antidepressants – making the brain more flexible and fluid, and less entrenched in the negative thinking patterns associated with depression”.

1000 mg Of EPA Fatty Acids Per Day

What makes fatty acids a great choice for mental health issues is that they can easily travel through the brain cell membrane and interact with mood-related molecules inside your brain. 

Recently, Oxford published a study that discussed fatty acid’s benefits throughout life.

Fatty acids have been studied in many mood disorders, such as postpartum depression, bipolar disorder, schizophrenia, obsessive-compulsive disorder, attention deficit disorder, and borderline personality disorder.

Why Do EPAs Help The Brain?

The brain contains more than 100 billion cells and omega-3 fatty acids are the building blocks of these cells. 

Fatty Acids bind to cell membranes increasing their fluidity, which is important for the functioning of brain cells.

PubMed says that essential fatty acids (EFAs) are essential for the maintenance of optimal health but they cannot be synthesized by the body and must be obtained from dietary sources. 

Clinical observation studies have related imbalanced intake of fatty acids to impaired brain performance and diseases.

Dealing with depression, anxiety, or both can make simple daily tasks a struggle. Sometimes, leaving the house, or just the bed feels impossible. 

So….

When you can’t make it to Superhuman IV’s physical location at 5th + Broadway, we will come to you with our in-home services and the most innovative treatments available out there.

One of our goals at Superhuman IV is to help as many people as possible with mental health battles with natural, nutrient-based iv therapy that has lasting results. 

We want to serve you the way we have served our other clients who have seen significant results. 

One of our favorite stories is about Maria, a 26-year-old who has battled severe fatigue and depression for decades. After one of our mini NAD+ mental health protocol treatments, Maria saw a night and day difference. 

Maria says that Superhuman IV has changed the game, she was struggling with depression, anxiety, and panic attacks.

But,  after the mental health 3-day NAD+ package, she hasn’t had a depressing day or panic attack since. 

NAD+ IV Treatment helped Maria change her thought patterns, sleep, and mood!

Read Maria’s story with Superhuman IV using the link: MARIA’S REVIEW

*These statements have not been evaluated by the FDA and are not intended to diagnose, cure or treat deep depression or other psychological disorders. We recommend you consult with your therapist or doctor before beginning any treatment. 

References:

NAD+ IV  : Affects mental health, supports physical health and helps people get super vital and energetic (Webmd: NADH, Overview, Uses, Side Effects, And More.., 2020, view reference)

(The National Library of Medicine: NAD+ in Brain Aging and Neurodegenerative Disorders, 2020, view reference)

Ketamine affects mood, thought patterns, and cognition  (Medscape: Ketamine Linked to Reduced Suicidal Thoughts, Depression, Anxiety, 2022, view reference)

(Scientific American: Behind the Buzz: How Ketamine Changes the Depressed Patient’s Brain, 2019, view reference)

Both Ketamine and psilocybin play a key role in reducing anxiety and depression levels. (Mayo Clinic: Treatment resistant-depression, 2021, view reference)

Psilocybin affects attitude about self & life, relationships, behaviors, and mood.

(National Library of Medicine: Psilocybin for Treating Psychiatric Disorders: A Psychonaut Legend or a Promising Therapeutic Perspective?, 2022, view reference)

(Medscape: Psilocybin Effective Up to 12 Weeks in Severe Depression, 2022, view reference)

(University of California San Francisco, Psilocybin Rewires the Brain for People with Depression, 2022, view reference)

EPA Fatty Acids help with depression, heart disease, rheumatoid arthritis, menstrual pain, and many mood disorders. (Oxford Academic: Omega-3 Fatty Acids EPA and DHA: Health Benefits Throughout Life, 2012, view reference)(PubMed: Essential fatty acids and human brain, 2009, view reference)

Can NAD+ Benefit Those Suffering from HIV and Aging?

Can NAD+ Benefit Those Suffering from HIV and Aging?

Fourteen years ago, September 18, 2008, the National Institute of Aging (NIA) launched National HIV and Aging Awareness Day. In the late 80s, very few people that were diagnosed with what is now known as human immunodeficiency virus (HIV) were lucky to survive past a year. During that time, many of the people living with HIV were taking highly toxic prescriptions and staying silent in hopes of surviving an epidemic. As treatments got better so did the lives of those suffering in silence. Although the HIV drugs used now are more effective and less toxic than drugs used in earlier times, they still may have long-term effects that we do not yet fully understand. So it’s not a surprise as we are hearing more people surviving to the normal lifespan.

The Ryan White HIV/AIDS Program (ADAP) serves over half a million individuals over 50 with HIV. In 2019, 92.2% of those aged 50 and older receiving HIV medical care were virally suppressed, which was higher than the national average (88.1%).

According to the Centers for Disease Control and Prevention (CDC), in 2018, over half (51%) of people in the United States that are diagnosed HIV were aged 50 and older. In addition, people aged 50 and older accounted for 17% of the 37,968 new HIV diagnoses. Though new HIV diagnoses are declining among people aged 50 and older, around 15% of diagnosis were those classified to be HIV and aging group.

People living with HIV have a lot more issues related to their aging than their HIV-related illnesses. Many individuals with HIV who have been living with it since the very beginning of the epidemic have unique difficulties, both physically and psychologically. 

How Does HIV Affect the Body’s Aging Process

HIV has an “early and substantial” impact on aging in infected people, accelerating biological changes in the body associated with normal aging within just two to three years of infection, according to a study by UCLA researchers and colleagues.

The findings suggest that new HIV infection may rapidly cut nearly five years off an individual’s life span relative to an uninfected person.

“Our work demonstrates that even in the early months and years of living with HIV, the virus has already set into motion an accelerated aging process at the DNA level,” said lead author Elizabeth Crabb Breen, a professor emerita at UCLA’s Cousins Center for Psychoneuroimmunology and of psychiatry and biobehavioral sciences at the David Geffen School of Medicine at UCLA.

“This emphasizes the critical importance of early HIV diagnosis and an awareness of aging-related problems, as well as the value of preventing HIV infection in the first place.”

Living with HIV presents certain challenges, no matter what your age. But older people with HIV may face different issues than their younger counterparts, including greater social isolation and loneliness. The aging process itself can lower energy levels, restrict social encounters, and cause decreased physical and mental abilities. This means that older people living with HIV may suffer more emotional problems and physical stresses than others do.

Stigma can also make things difficult. There is the stigma from shame of living with HIV, AIDS, and older adults. This can make it difficult for older people to find support. First of all, they may be ashamed and hesitate to tell anyone that they live with HIV. Secondly, they may not be comfortable in support groups that include younger people.

In the late 80s many HIV cocktails (ART) regimens required people to take several pills around the clock. Even today with the huge improvements in HIV drugs that now allow most people to live long and healthy lives with HIV, there are several ways in which living and aging with HIV are different than others over 50 years old.

HIV and its treatment can also have effects on the brain. Researchers estimate that between 25 and 50% of people with HIV have HIV-Associated Neurocognitive Disorder (HAND), a spectrum of cognitive, motor, and/or mood disorders categorized into three levels: asymptomatic, mild, and HIV-associated dementia. Researchers are studying how HIV and its treatment affect the brain, including the effects on older people living with HIV.

Can NAD+ Slow Aging for those Aging with HIV?

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme that’s been shown to slow aging and help people fight the ill effects of aging. As biohacking evolves it’s been found to mitigate age-related disorders by regenerating the human body’s mitochondria. NAD+ is a key enzyme found in human cells and has been shown to reduce the amount of age-related tissue damage and by increasing the nutrients that keep skin looking young. It also improves muscle function and endurance and helps ward off age-related diseases. Recent research has shown that NAD+’s rehabilitation power extends the cells.

“We report that HIV-1 infection of human cells in vitro leads to significant decreases in the intracellular concentration of NAD. This decrease varies with viral load and HIV strain. In tissue culture, cells lacking CD4 receptors or cells incubated with heat inactivated virus do not demonstrate this decrease in NAD. Nicotinamide, the amide form of the vitamin niacin, increases intracellular NAD levels in uninfected cells as expected. Our data demonstrate that nicotinamide also maintains increased intracellular NAD concentrations in HIV infected cells. We conclude that HIV induces a state of intracellular pellagra which is reversed by the administration of nicotinamide.”

The team examined five epigenetic measures of aging. Four of them are what are known as epigenetic “clocks,” each of which uses a slightly different approach to estimate biological age acceleration in years, relative to chronological age. The fifth measure assessed the length of telomeres, the protective cap-like ends of chromosomes that become progressively shorter with age as cells divide, until they become so short that division is no longer possible.

“Our access to rare, well-characterized samples allowed us to design this study in a way that leaves little doubt about the role of HIV in eliciting biological signatures of early aging,” said senior author Beth Jamieson, a professor in the division of hematology and oncology at the Geffen School. “Our long-term goal is to determine whether we can use any of these signatures to predict whether an individual is at increased risk for specific aging-related disease outcomes, thus exposing new targets for intervention therapeutics.”

If you feel good about your age, it can help your health. As the saying goes, you’re only as old as you feel!

Sources

Research from the National Library of Medicine*

HIV Services Locator

Can NAD+ Benefit Those Suffering from HIV and Aging?

My Journey Through the Postpartum Waves and How NAD+ is the Liferaft I Needed

Before I gave birth to my daughter in the summer of 2021, I knew I was predisposed to postpartum mental health issues.

My common sense told me, the books I was reading told me, and my birthing team told me. I have a history of depression and anxiety issues that stem back at least two decades; running the spectrum from social anxiety to several suicide attempts.

This made me tremendously more likely to develop issues after giving birth, they said. They also said that if it happened within the first six weeks of the postpartum time period, that was normal and to-be-expected. Baby Blues, it’s called. But if it happened after that first six weeks? Well, that was much more serious.

Just how serious, they couldn’t say. And could they do anything to prevent it? No, they could not.

“It” was severe Postpartum Depression and Anxiety, and after the initial six-week postpartum time period had come and gone, it was clear I had a bad case of it.

When I was checked out of my last birthing appointment, my midwife gave me a form called the Edinburgh Postnatal Depression Scale and had me check little boxes that stated I had support during this time and no, I wasn’t feeling like harming anyone I loved, including my precious newborn daughter. It asked how often I was feeling happy and whether I’ve been sleeping and do I blame myself when things go wrong?

I answered truthfully. Yes, I’ve felt sad or miserable much of the time. YES, I’ve been so unhappy that I’ve been crying. And no….who the heck is able to laugh and see the “funny side of things” when you are waking up every two hours to feed a tiny, fragile little creature, who then won’t go back to sleep on her own and who is too little to sleep with you?

I was barely surviving.

Still, my midwife checked and signed the release sheet on her clipboard, made certain that I had good support at home (namely, my also-exhausted husband) and sent me on my (not-so merry) way.

“Is this normal?” I asked myself the whole way home. “Should have I checked the box that asked me if I felt like harming someone? Would that have changed this medical professional’s response?”

Who actually knows. Maybe I’d have been put in touch with a mental health professional. Maybe.

But supplement recommendations? No. Helpful exercises? No. Herbs to help with mental issues that are okay for breastfeeding? No. A friend group for other moms like me; the not-so-joyful, crying-half-the-day ones? Nopety nope nope nope.

It all came to a head when my daughter had just turned one. I wasn’t better mentally; I was worse. After spending one particular long evening in the bathtub, determined to never emerge from it again, my husband and I decided to get real help.

Real help looks like many different things for people. For us, having tried so many other things, this was trying intravenous treatment: IV therapy.

The major nutrient I was signing up for NAD+, a coenzyme that is used in every cellular function in the body. We are born with a finite amount of it, but by the time we are fifty, half of it is depleted, gone, caput, usually aided by stress and sometimes traumas. If you’ve had a lot of traumas or stress in your life, it’s a high chance that your NAD+ levels are much lower than an age peer with a low-stress lifestyle.

I have a high ACE score of childhood trauma, so going into this, I knew my levels were likely very low. Low levels of NAD+ are strongly correlated with addiction issues as well as mental health issues of PTSD, anxiety and depression.

Per most things in my life, once I decided on NAD+, I decided to go all the way. I settled on high-dosage treatments of 500 and 1,000 milligrams per treatment, which are typical dosages for treating issues like depression. I was warned repeatedly that high-dosage treatments can cause detox symptoms, but with the suffering I was already enduring, what was something more if it helped in the end?

Cue the “suffering”.

The first thing I noticed (literally while the fluid was still chugging into my veins) was a sense of calm that began to come over me just several minutes into the treatment. That calm turned into—for lack of better description—what felt like a light buzz from a glass or two of wine. But as every cell in my body began to detox, I started to feel sick.

The detoxing continued for a few hours after that first high treatment. It knocked me on my back, making my body feel like it had the flu and making my mind wonder if I’d made the right decision to replenish my NAD+ levels. Maybe the levels taper off for a good reason?

And then, after the few hours, around ten ‘o clock at night, I started to feel as if a cloud was lifting off my very body. A lightness emerged, down to my chronically tired joints. Suddenly I felt as if I could clean my bedroom, clean the house, do some laundry—which, although usually unheard of for me at that time of day—I did. In fact, I had so much energy that I told my husband he was probably going to have to go to bed without me.

My brain was so used to being tired that I figured I’d better make use of this rare energy spurt.

That “rare energy spurt” continued for a few days, making even sleep difficult at first. After those few days, sleep returned to me, easier than ever before. I found that I was exhausted by 10 pm. However, when 7 am rolled around the next morning, I was bouncing out of bed. And this has never, never happened for me. For most of my adult life, I’ve been the person staggering to the kitchen at eight in the morning, trying to fumble my glasses on and make a decent cup of coffee which I proceed to down in just a few gulps.

But here I was at seven in the morning, unsure I even felt like drinking coffee. I even switched to mushroom coffee, which has far less caffeine, and I only drink one cup of it, once a day. Before my treatment, I was drinking coffee in the morning, coffee in the late morning, and at least one caffeinated drink in the afternoon.

Now that’s a story belonging to my past.

It’s been several weeks since my last high-dosage treatment of NAD+. I can honestly say, hand on my heart, that my life has been changed for the better.

Do I still have depressed moments that hit me like a freight train? Yes. Yes, I do. NAD+ is no magic bullet or substitute for spiritual and emotional healing. It’s not your therapist in an IV, even though it may feel that way.

But what has changed makes NAD+ worth more than its weight in gold to me: when I do have a surge of panic or a depressed episode, it doesn’t last nearly as long or feel quite as disparaging. Now my episodes last thirty minutes to an hour, with much greater control, than my episodes of the past that lasted sometimes multiple days, during which I felt I had very little control indeed.

I will never forget the night I finished my first high dosage treatment. I was sitting in the bathtub still feeling like I had the flu, when suddenly my now fourteen-month-old daughter began screaming in the other room. It wasn’t an I’m Bleeding and I Need to go to the Hospital scream. It was just an ordinary scream. But even ordinary screams were enough to send me into a mild panic attack—palms sweating, heart racing, nausea building. Almost every day since she was born, I’d experienced at least one episode like this. But this night, for some weird reason, I felt a strange distance from the screaming. I wasn’t disassociated from my child; I was disassociated from the panic. I felt a space within which I was able to decide how to react. So I evaluated the scream, decided that she was not injured, and reasoned with myself that her father was taking fantastic care of her, all in the space of a few seconds. And then, of course, I marveled at what I’d just done.

As if that wasn’t life-changing enough, though, I soon realized I had buckets more energy than I used to, all day long, until the clock reached ten pm.

And then I realized I can be present for my daughter without wanting to stay in bed or in the bath crying all day and night.

I regained the desire to work out and it’s no longer like pulling teeth for me to make plans and follow through on seeing my friends.

The dreaded brain fog has lifted and not returned, not even a little bit.

My metabolism has sped up to the rate of my mid-teens; no longer do meals sit in me for days, even if it’s pasta I’m indulging in. I have a sense of lightness that’s more than just a lightness in my gut; it’s a lightness for life itself.

I’m sleeping better, eating better, waking easier, working with greater clarity and laughing a whole lot more.

Now that I think about it, life-changing might be an understatement.

It was more like life-shattering for me.

I feel like my spirit is caught up in one of those corny TV commercials for antidepressants, running through fields of flowers and swinging on a hammock in a forest, only without the dreaded side effects. Because unlike many drugs, there are no long-term side effects. NAD+ is simply a cellular nutrient that we had in copious amounts as babies.

The best part of all is that I don’t feel dulled or hyped in any way. I don’t feel like the artificial version of myself; I feel like the authentic me who got stuck for awhile, just a little voice screaming while drowning beneath the proverbial waves of the postpartum period, but who received a life raft just in time; the me who always wanted to feel capable, and who now is capable.

While it may not be this way for everyone, for me, intravenous NAD+ was the liferaft I needed. I now feel strong enough to handle anything thrown my way, whether that thing is postpartum hormones, anxiety, depression, or just pesky old childhood trauma.

For the first time in my life—as a wife and now as a mother—I’m not only surfing those waves; I’m commanding them.

Why IV Therapy Is Here To Stay And Why You Need It

Why IV Therapy Is Here To Stay And Why You Need It

No, it’s just not you; IV Therapy really is everywhere these days. In fact, it’s one of the hottest new health trends to be raved about in decades. 

Brad Pitt was an early adopter of the famous Myer’s Cocktail to help him look and perform his best onscreen. Madonna is a fan of intravenous Vitamin B12. Justin Bieber gets weekly NAD + treatments. Kendall Kardashian underwent an NAD+ IV treatment on her family’s new show, The Kardashians. Everyone from Sofia Vergara to Jane Fonda and Gwyneth Paltrow rely on IV therapy to achieve maximum nutrient absorption. 

So what are the facts? 

1. We’re not getting the benefits of all the supplements we take…and for a very good reason. 

Just for context, I’m that person who used to take as many as thirty different supplements every day for months. I had entire cabinets in my kitchen dedicated to the many different types. 

But here’s the problem. 

Supplements have an absorption rate of 10-30%. This is because supplements have to undergo a complex process before their nutrients are absorbed into the bloodstream and carried by cells to the brain and other organs. Supplements have to be digested and digestion takes time. 

But it also means that in order to achieve that top-end 30% absorption from the pills you are swallowing, your gut has to be in fantastic shape (no gastro issues, no leaky gut, etc) and you have to be consuming top-of-the-line, high-quality supplements.  

So if you’re like the average American with poor gut quality, popping vitamin C from Walgreens or Costco, chances are your absorption rate is around that bottom-end, measly 10%. 

If you’re super-healthy, with a near-perfect gut, taking expensive, well-produced supplements, you might be able to achieve thirty whole percent. 

This means that for most of us, it’s pointless to rely on supplements to combat any real issues or achieve truly optimum health. 

So what if you could get 50% absorption from a nutrient modality? What about 70%? 

IV therapy is the only nutrient-delivery system currently on planet earth that allows almost 100% absorbency. And why is that? Just think about it: all of the work your body normally has to do to break down your pills is completely omitted. Instead of waiting for your pills to kick in, the nutrients are immediately bioavailable as they pour into your bloodstream. 

From there, the nutrients are absorbed and carried by your cells all throughout your body. 

It doesn’t matter if you have the healthiest gut on planet earth. Your gut can only do so much work absorbing the nutrients you swallow. IV therapy is how you can achieve the highest absorption, quickest activation and longest-lasting nutrient system. 

And here at Superhuman IV, we’ve made it even easier for you. Instead of leaving the comfort of your home and signing into a medical clinic, with a few taps of your buttons or screen you can schedule a trusted Superhuman RN to come to your home, place of business or even hotel, and we will treat you with an IV there. Wherever you’re at, we can treat you. 

You can simply kick back with your favorite book or show while our RNs administer nutrients that will all be absorbed into your body and help you feel better-than-ever. 

If you’re traveling with friends, you don’t even have to halt your conversation. If you’re at work, you don’t even have to stop writing emails, and if you’re home, you can even stay in your pajamas. 

Book your first IV therapy today. 

Because when you feel better, you do better.