Hope For Every Person Suffering From Depression: NAD+, Ketamine, & Psilocybin Offer Hope

Acute depression may be a normal occurrence.

This will typically go away on its own within a few days.

On the other hand, according to WebMD, chronic depression persists for weeks, months, and, sometimes, maybe years!

This may feel like a sadness that won’t go away on its own…

People may battle depression as a result of external factors like family, work, and study issues, or the changing of the seasons.

But sometimes, environmental factors may not be the reason, instead, a neurological condition may affect a person’s thought patterns which require lifestyle changes, medical treatment, and IV therapy.

Today, NAD+, Ketamine, and Psilocybin are opening new doors and giving hope to people suffering from depression for many reasons we’ll list in this article…

Let’s start with NAD+

NAD+ IV Therapy

 According to PubMed, NAD+ (Nicotinamide adenine dinucleotide) is a coenzyme that our bodies naturally produce and it  plays a key role in:

  • Reversing mitochondrial damage
  • Improving cellular function
  • Reducing oxidative stress
  • Reducing inflammation
  • Promoting brain and neurotransmitter regeneration

Apart from the functions it performs, NAD+ is also required for many enzymatic activations like the ones including Sirtuins.

Patients suffering from mental health disorders have low levels of these NAD-dependent enzymes

In addition, in depressed people, changes in the hippocampus reduce the functions of the neurons.

So, using NAD+ IV for depression helps boost the levels of Sirtuins. SIRT 1 (a subclass of these enzymes) that’s responsible for mediating neurotransmitters in the brain to reduce anxiety and depression levels.

Other subclasses like SIRT1, SIRT2, SIRT3 have a positive impact on the overall brain health as they prevent neuro-degeneration, promote neuronal growth, reduce inflammation and damage in neurons.  

Ketamine for Depression

Ketamine is used for people suffering from serious mental issues who have tried other medications with no relief.

This treatment is mainly used for people with treatment-resistant depression, acute suicidality, PTSD, OCD, bipolar, and eating disorders.

Ketamine triggers glutamate production, cascading a series of events that prompt the brain to form new neural connections.

Glutamate encourages the growth of synapses in the brain, and strengthens neural connections in the regions that are most impaired by depression; these new connections induce beneficial changes in brain circuit function.

This process makes the brain more adaptable and able to create new pathways, and gives patients the opportunity to develop more positive thoughts and behaviors.

Ketamine works very quickly within hours  to ease symptoms and stimulates brain changes that lead to lasting symptom relief.

Psilocybin for Depression

Psilocybin is an active ingredient found in many species of mushrooms called ‘magic mushrooms’

This material makes the brain more flexible, produces immediate effects, and has a long duration (weeks after use for people with depression).

These features make it a uniquely useful new treatment for depression.

The National Institute on Drug Abuse (NIDA) notes that psilocybin alters people’s perception and awareness of their surroundings, thoughts, and feelings.

The scans performed on the brain after psilocybin therapy showed that it reduced connections within brain areas that are connected in depression, like the default mode, salience, and executive networks, and increased connections to other regions that had not been integrated.

All of these features prove that psilocybin works differently from conventional antidepressants by making the brain flexible, fluid, and less entrenched in the negative thinking patterns associated with depression.

Anyone who’s ever experienced sadness understands how much of a damper it can put on the day.

But… chronic depression is more than just having a “bad day”, it may mean having an unhealthy relationship to self, others, and life.

The American Psychiatric Association recognizes depression as a serious medical illness that negatively impacts how a person feels, thinks, and lives.

Also, The World Health Organization says that depression will be the second leading cause of death by 2030. 

If common antidepressants can not fully treat a person’s depression, these innovative treatments are able to provide hope and help people suffering with depression reclaim their lives.

NAD+, ketamine, and psilocybin treatments for depression can be a useful co-therapy for traditional methods such as medication and lifestyle changes.

Superhuman IV brings appointments directly to you at home or at the office to enjoy the benefits of these innovative treatments.


In modern diagnostic classification systems, dysthymia and chronic depression are now both referred to as persistent depressive disorder.

(Webmd: Dysthymia (Mild, Chronic Depression), 2022, View reference).

NAD+ influences many key cellular functions, including metabolic pathways, DNA repair, chromatin remodelling, cellular senescence and immune cell function. 

(PubMed: NAD+ metabolism and its roles in cellular processes during ageing, 2022, View reference). 

NAD+ plays an important role in the regulation of NAD+-consuming enzymes, including sirtuins.

(National Library of Medicine: NAD+ and Sirtuins in Aging and Disease, 2015, View reference).

Treatment-resistant depression is the depression that doesn’t respond to two different antidepressants from different classes. 

(Webmd: Treatment-Resistant Depression, 2022, View reference).

Ketamine is used for people suffering from serious mental issues with no relief after using medications.

(Psycom: Ketamine for Depression, 2022, View reference).

Hallucinogens are a diverse group of drugs that alter a person’s awareness of their surroundings as well as their own thoughts and feelings.

(The National Institute on Drug Abuse: What are hallucinogens?, 2021, View reference).

Depression will be the second leading cause of death by 2030. (World Health Organization: Depression, 2021, View reference).

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